“three ‘E’s” in immune therapy: elimination, equilibrium, and escape.

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

Make sure to keep in mind this report from the NEJM next time you think of rational design of cancer therapies.

http://www.nejm.org/doi/full/10.1056/NEJMoa1112824

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

Michael A. Postow, M.D., Margaret K. Callahan, M.D., Ph.D., Christopher A. Barker, M.D., Yoshiya Yamada, M.D., Jianda Yuan, M.D., Ph.D., Shigehisa Kitano, M.D., Ph.D., Zhenyu Mu, M.D., Teresa Rasalan, B.S., Matthew Adamow, B.S., Erika Ritter, B.S., Christine Sedrak, B.S., Achim A. Jungbluth, M.D., Ramon Chua, B.S., Arvin S. Yang, M.D., Ph.D., Ruth-Ann Roman, R.N., Samuel Rosner, Brenna Benson, James P. Allison, Ph.D., Alexander M. Lesokhin, M.D., Sacha Gnjatic, Ph.D., and Jedd D. Wolchok, M.D., Ph.D.

N Engl J Med 2012; 366:925-931March 8, 2012

The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer–testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.)

T-CELL ARMY

For those of you who have accesso to the New Yorker, please have a look to this article. A nice commentary of the Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma on the New England Jorunal of Medicine of March 8 and latest reports of advances in Immunotherapy of Cancer

Read more at http://www.newyorker.com/reporting/2012/04/23/120423fa_fact_groopman#ixzz1sIutyBzV

T-CELL ARMY

Can the body’s immune response help treat cancer?

by Jerome Groopman